MONAI before 1.6.0 Remote Code Execution via NumpyReader (CVE-2026-100845) | HOL Guard CVE

High · CVSS 8.5CVE-2026-100845

MONAI before 1.6.0 Remote Code Execution via NumpyReader

Answer in brief

CVE-2026-100845 records a High severity (CVSS 8.5) vulnerability in MONAI before 1.6.0 Remote Code Execution via NumpyReader. The current sources do not mark it as known exploited. The current feed maps Project-MONAI/MONAI (generic). Check affected ranges and fixed versions before updating.

Analysis pending evidence review

HOL Guard separates source facts from reviewed analysis. See the methodology.

Published Sep 27, 2026Updated Sep 27, 2026Source checked Sep 27, 2026First seen by HOL Sep 27, 2026Material review Sep 27, 2026

Upstream Advisory

Key facts

Risk: High · CVSS 8.5
Exploitation: Not marked as known exploited
Affected software: 1 mapped package or product
Fix availability: Available

Why this deserves its current priority

CVSS is 8.5. The current sources do not mark it as known exploited. Treat this as a source-backed prioritization signal, not a statement about your environment.

Analysis status

Analysis pending evidence review

Factual feed record only; HOL analysis is not approved for indexing. Read the methodology.

Affected scope and exposure questions

The current feed maps Project-MONAI/MONAI (generic). Check affected ranges and fixed versions before updating.

Mapped affected packages and fixed versions
Package	Affected range	Fixed version
Project-MONAI/MONAIgeneric	>=0 <1.6.0	1.6.0

Recommended response

Check inventory. Check lockfiles and deployed manifests for Project-MONAI/MONAI.
Review the reported fix. Update Project-MONAI/MONAI to 1.6.0 if you use the affected versions. Test the change in a non-production environment first.

Evidence timeline and material changes

Published upstream
Sep 27, 2026
Evidence: source:cvelist:source_dates:source-dates:record
Source modified
Sep 27, 2026
Evidence: source:cvelist:source_dates:source-dates:record
First seen by HOL
Sep 27, 2026

Sources and claim methodology

Upstream source description

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

Quoted source text, attributed separately from HOL analysis.